Some foods commonly enjoyed by humans are dangerous to dogs, including chocolate (Theobromine poisoning), onions, grapes and raisins,^[13] some types of gum, certain sweeteners^[14] and Macadamia nuts. It is currently believed that the only dangerous substance in chocolate is cocoa, meaning that forms of chocolate without this ingredient, such as white chocolate may become re-evaluated for their safety in future.

The acute danger from grapes and raisins has been uncovered only since about 2000, and made public slowly since then. At present the cause is not known. Whatever the reason, since only small quantities are necessary to induce acute renal failure, dogs should not be fed grapes or raisins, and sultanas and currants should likely be withheld as well.

Cooked bones should never be given to dogs, as the heat changes the chemical and physical properties so that they cannot be chewed properly, splintering into jagged shards, and resist digestion.

Human medications should not be given to a dog as a substitute for their regular medication as some can be especially toxic, especially paracetamol/acetaminophen (Tylenol). Alcoholic beverages pose much of the same hazards to dogs as they do to humans.

Dogs may also find some poisons attractive, including antifreeze, snail bait, insect bait, and rodent poisons. Antifreeze may be one of the most insidious of poisons to dogs because of its sweet taste and because a dog may walk upon or lie down upon a spill of it or its residue and then lick it off. Dogs must be kept strictly away from antifreeze and not allowed access to any place that has had a spill of it that has not been completely removed.

Plants such as caladium, dieffenbachia and philodendron will cause throat irritations that will burn the throat going down as well as coming up. Hops are particularly dangerous and even small quantities can lead to malignant hyperthermia.^[15]

Amaryllis, daffodil, english ivy, iris, and tulip (especially the bulbs) cause gastric irritation and sometimes central nervous system excitement followed by coma, and, in severe cases, even death.

Ingesting foxglove, lily of the valley, larkspur and oleander can be life threatening because the cardiovascular system is affected. Equally life threatening is the yew which affects the nervous system. If any of these plants are ingested, get the dog to a veterinarian immediately.

Many household cleaners such as ammonia, bleach, disinfectants, drain cleaner, soaps, detergents, and other cleaners, mothballs and matches are dangerous to dogs, as are cosmetics such as deodorants, hair coloring, nail polish and remover, home permanent lotion, and suntan lotion.

Zinc toxicity, mostly in the form of the ingestion of US pennies minted after 1982, is commonly fatal in dogs where it causes a severe hemolytic anemia.^[16]

Dogs will occasionally eat their own feces or the feces of other species if available, such as that of cats and horses. This is known as coprophagia, and may be indicative of boredom or hunger, although there is no definitive reason known. Owners of both cats and dogs may find that dogs treat the catbox as a snack bar. Such behavior should be discouraged, as it could lead to Toxoplasmosis.